Fraction collection and Lc-MS analysis
1 June 2017

New possibilities for detailed characterization of product related impurities

Most laboratories use Size Exclusion (SEC), Ion Exchange (IEX) and Reversed-Phase chromatograph (RP HPLC) as part of a their protein characterization analysis. The chromatography may leave you with questions about the identity of specific peaks and shoulders in your chromatogram. A molecular weight analysis of the peaks by mass spectrometry will often identify the molecule. For reverse phase HPLC you can… Read whole story

Host Cell Protein Conference
16 May 2017

BEBPA 2017 – Key topics and take-home messages

The BEBPA Host Cell Protein (HCP) workshop meeting was again held in charming San Francisco with HCP experts from all over the world. 140 engaged participants from biopharma companies, instrument vendors, CRO’s and regulatory authorities had a very good meeting with high level presentations and an excellent forum for discussion and interactions. Pre-conference educational workshops… Read whole story

Identification and Quantification of HCP’s by SWATH LC-MS for Process Development of a Novel Biologic
1 May 2017

Thomas Kofoed, CEO at Alphalyse presenting at the BEBPA 2017 Host Cell Protein Conference in San Francisco this May

We’re proud to announce that Alphalyse returns as platform presenter at next week’s Host Cell Proteins conference. The event, organized by BEBPA, takes place on 10-12 May in SF, California. Join our presentation to learn how to complement ELISA assays with SWATH LC-MS data from Alphalyse. SWATH LC MS is a new technology which may completely change the way… Read whole story

Host cell protein impurities
28 April 2017

Public funding awarded to Alphalyse for development of a method to improve the safety of biopharmaceuticals

Alphalyse has received a large grant for developing a method to identify and quantify the host cell proteins (HCP) in a drug sample. The project takes place in close cooperation with the Swedish biopharmaceutical company Hansa Medical and University of Southern Denmark (SDU). It is a well-known fact that HCP impurities in biopharmaceuticals can cause severe side… Read whole story

4 November 2016

Alphalyse steps up with two new employees

As of 1st of November, Alphalyse welcomes two new colleagues; Fen Yang and Lis Jakobsen. Fen and Lis join our team of highly dedicated protein scientists. Thus, they will take on the responsibility of helping our customers within the biopharmaceutical industry solve protein analysis issues – mainly related to protein characterization and quantification. The two new employees bring many… Read whole story

Market development fund awards Alphalyse grant for HCP validation project
3 November 2016

Funding received to validate Host Cell Protein analysis using mass spectrometry

Alphalyse has received a large grant, which we will use to test and validate our newly developed LC-MS/MS methods for Host Cell Protein (HCP) analysis. The testing takes place in close collaboration with an American biotech company. The collaboration seeks to change the way the industry measures HCP in biopharmaceuticals. We aim for a validated HCP test method, for making it both faster… Read whole story

7 October 2016

New detailed characterization service for antibody drug conjugates (ADCs) with various DAR distributions

Alphalyse participates in the annual Eurostars event in Belgium on 13 October. Marie Grimstrup, innovation manager, shares experiences from a Eurostars project. Marie has lead the Alphalyse part of the project since 2015, in collaboration with ChromaCon in Switzerland. Together we develop purification technologies and analytical methods for antibody drug conjugates (ADC). Detailed characterization of antibody drug conjugates (ADCs) with various DAR distributions… Read whole story

Agilent fraction collection
21 September 2016

Identify & quantify a host cell protein with high homology to drug substance protein

In a new HCP blog post at the Protein Analysis Blog Rikke Raaen Lund, PhD and protein expert at Alphalyse, describes how you can use mass spectrometry (1D SDS PAGE and nanoLC-MS/MS) to identify and quantify a specific host cell protein in your drug substance. A host cell protein with high homology to your drug… Read whole story

MS Øresund 2016
17 September 2016

Thomas Kofoed presenting at the BioAnalytical and Formulation Summit in Berlin

Thomas Kofoed, CEO, Alphalyse will be presenting on Wednesday, 14 September 2016 at the Evening Seminar: “Pioneering downstream processing: information and discussion for HCP clearance”  together with Milla Neffling from Sciex Biologics, UK. Thomas Kofoed will describe how a consortium consisting of Alphalyse, Statens Serum Institute (SSI) and the Protein Research Group at University of Southern Denmark… Read whole story

Unboxing the new mass spectrometer for protein analysis
23 August 2016

How you turn a mass spectrometry transportation box into hours of play and joy!

We do not normally create DIY guides – as we are more of a SOP company.  But we simply have to share this Do-It-Yourself project with you, because the result was so surprising and awesome! Some months ago, our much anticipated TripleTOF® 6600 system arrived in a gigantic wooden transportation box. After unboxing the new mass spectrometer, the… Read whole story

6 June 2016

Alphalyse launches new website and new protein analysis services

We have launched a new array of protein analysis services on the Alphalyse website. These include Peptide Mapping, Antibody Characterization and Host Cell Protein Analysis . You’ll find many other new products on our website. You can now order any protein analysis in less than 10 minutes We introduce a new intuitive order flow. Ordering is now… Read whole story

Danish Ecommerce Awards
23 May 2016

Alphalyse announced first runner-up in Danish Ecommerce Awards

On Wednesday 18 May, the Danish Ecommerce Awards announced the winners and runners-up in twelve categories . Tivoli Gardens Congress Center in Copenhagen hosted the venue, in beautiful surroundings. Alphalyse was nominated for one of the prestigious awards for the very first time. Thus CEO Thomas Kofoed was happily surprised when announced as first runner-up for the award in… Read whole story

20 May 2016

Alphalyse presents at BEBPA Host Cell Protein Conference in Lisbon

Combining Platform ELISA and Mass spectrometry for HCP analysis Ejvind Mortz, COO at Alphalyse, together with David Chimento from Rockland immunochemicals presented on Day 1 of the annual BEBPA HCP conference in Lisbon on May 17-19. The topic was “HCP Analysis of a small drug-protein in process sample by Combining Platform Immunoassays and Mass Spectrometry”…. Read whole story

29 April 2016

Alphalyse receives Top 5 nomination for Danish E-commerce Award 2016

Alphalyse has been nominated for the Danish E-commerce Awards 2016, which is organized by the Danish E-commerce Association (FDIH), to recognize excellent Danish e-commerce companies. The award is presented in 12 categories, and Alphalyse is nominated for the Cross-Border Award 2016. The Cross-Border Award is given to the company, which uses the online-channel in an excellent… Read whole story

MS Øresund 2016
1 April 2016

Alphalyse presents at MS Öresund: User meeting for LCMS-users in the Copenhagen-Malmö-region

COO, Ejvind Mortz, presents at the MS-Öresund conference. He gives his view on Host Cell Protein Analysis Strategies for Protein Biopharmaceuticals using LC MS/MS and explains how our scientists use specialized LC MS/MS techniques to quickly and accurately identify HCPs in complex biopharmaceutical samples. Download program

difference between 1d and 2d gel electrophoresis
17 March 2016

Genovis AB has signed a strategic cooperation agreement with Alphalyse A/S

The cooperation agreement provide Genovis with access to Alphalyse’s expertise in mass spectrometry while Alphalyse will have the opportunity to offer its customers analyses based on Genovis’ unique enzymes for antibodies and other pharmaceutical proteins. March 17, 2016 – Much of Genovis’ customer base works with mass spectrometry in the analysis of biologics. Genovis and Alphalyse… Read whole story

Host cell protein laboratory
20 June 2014

Mapping proteins to make vaccines even safer

Every vaccine contains small quantities of proteins, however currently there is no analysis method capable of identifying and measuring the different protein residues. The Danish Innovation Fund invests six million Danish kroner in the development of a new effective method for mapping residual proteins. The vast majority of vaccines being developed today are produced in genetically… Read whole story

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