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Genovis enzymes as tools in protein analysis

Collaboration with: Genovis AB (Sweden)
Since 2016

Through this collaboration, our customers take advantage of analysis using unique Genovis enzymes. The enzymes are used for digest of antibodies and other pharmaceutical proteins.

Together, Alphalyse and Genovis actively test, develop and market new analytical methods based on Genovis enzymes. Our focus is on solving challenges with respect to analysis of large proteins that must be cut into smaller parts. This must be done in order to allow analysis by mass spectrometry.

Genovis produces unique enzymes and products that allow for digestion of large biopharmaceutical proteins e.g. antibodies, into smaller parts at various specific cleavage sites. The Genovis enzyme portfolio includes FabRICATOR® (IdeS), FabRICATOR®Z (IdeZ), FabULOUS® (SpeB), GingisKHAN® (KGP), GingisREX™ (Rgp), IgGZERO® (EndoS) and GlycINATOR® (EndoS2). The collaboration provides Alphalyse with expertise in using these enzymes in combination with mass spectrometry. Thus helping our clients with detailed characterization of their products, such as antibody drug conjugates for cancer treatment and de-novo-sequencing of new antibodies in the discovery phase.

View press release

Poster: Middle Level LC-MS Characterization of Site-Specific and Random ADC – Impact of In Vivo Tumor Uptake 


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