Antibody Characterization

Structural characterization of antibodies, ADC's and biosimilars

Are you looking for a professional antibody characterization service?

Alphalyse offers a whole range of analytical services for structural antibody characterization of monoclonal antibodies. We perform our tests according to the ICH Q6B guidelines – Test Procedures and Acceptance Criteria for Biotechnological/Biological Products.

Our optimized analytical antibody characterization services are suitable for monoclonal antibodies, antibody-drug-conjugates and also for antibody biosimilars.

You can choose and combine your preferred analysis package from the following services:

Molecular weight of mAb  >
We determine the exact molecular weight of both intact and reduced monoclonal antibodies.

Disulfide analysis of mAb  >
We determine the number and also the position of disulfide bridges in monoclonal antibodies.

Peptide mapping of mAb  >
We confirm the theoretical amino acid sequence of your monoclonal antibodies by peptide mapping.

De-novo sequencing of mAb  >
We determine the exact amino acid sequence of your monoclonal antibodies by de-novo sequencing.

Edman sequencing of mAb  >
We can sequence up to 30 residues from the N-termini of your antibody by N-terminal Edman degradation.

Antibody-drug conjugates  >
We determine the exact distribution of drug-to-antibody ratio (DAR). In addition we find the exact attachment site(s) of the drug molecule.

Send us your project description so we can design a service package that meets your needs.

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