Quantify HCPs of concern
- Determine HCPs specific to your process
- Obtain the exact amount in all purification steps
- Results to be used for removal of immunogenic and proteolytic proteins
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Set up meetingWe would like to help you as much as possible with your project and therefore provide several kinds of customer support:
The absolute quantification of specific protein in complex matrices are based on the selection of specific peptides as signature peptides and used for assay development based on Multiple-Reaction-Monitoring (MRM). The project are typically divided into three parts.
The purpose of the feasibility study is to investigate the possibility to develop an assay that can be used for the quantification of the specific protein in the matrix. The feasibility study will include:
Protein quantification by mass spectrometry requires a protein in sufficient amounts to obtain good data. It is important that samples are prepared in a clean laboratory to avoid contamination with human keratin. To develop MRM quantification assays requires the protein in pure form and a matrix sample without the protein similar to the matrix of the real samples to be analyzed.
Protein samples can be submitted in liquid or lyophilized.