Most biologics contain post-translational modifications (PTMs) and the characterization of these can be quite challenging.
Alphalyse offers a range of analytical services for determination of PTMs, including analysis of disulfide bridges and glycosylations.
The modifications are typically investigated using a combination of protein chemistry and mass spectrometry. Thus, the analytical design of these experiments requires deep understanding of the technology. This includes protein chemistry methods, advanced mass spectrometry instrumentation and software for data interpretation.
You can choose between the following PTM services:
- Disulfide bridge analysis of protein or mAb >
We determine both the number and position of all disulfide bridges in your drug substance protein or monoclonal antibody.
- Glycosylation analysis of protein or mAb >
We determine both the number and position of all glycosylations in your drug substance protein or monoclonal antibody.