Intact Mass Analysis
- Characterize modifications and degradation products
- Identify coeluting proteins or shoulders
- Suitable for proteins and monoclonal antibodies
Services
- Mass range 0-250 kDa
- Sample amount >5 ug
- Accuracy within 30 ppm (often 10 ppm)
- Exact MW of intact antibody
- Reduction and deglycosylation of antibody
- Exact MW of heavy and light chain and deglycosylated forms
- Comparison with the expected masses
- UV-LC trace & exact MW of proteins above 1%
- Customized UV-LC ESI-MS method; eg. column, gradient, MS conditions
- Accuracy +/- 2.5 Da
- Comparison with theortical MW of protein
- UV-LC trace & exact MW of peptides above 1%
- Customized UV-LC ESI-MS method; eg. column, gradient, MS conditions
- Accuracy +/- 2.5 Da
- Comparison with theortical MW of peptide
Protein Molecular Weight Determination
Results in 10-14 days
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Exact Molecular Weight of mAb including Deglycosylation
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Molecular Weight of Peptides – Customized Analysis
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