Alphalyse scientist successfully defends PhD thesis

2 May 2019

CONGRATULATIONS to Katrine Pilely who Tuesday successfully defended her PhD thesis at the University of Copenhagen.

Under supervision of Professor Peter Garred, Katrine Pilely studied how cholesterol crystals activate the immune system. This happens through complement-mediated mechanisms, and therefore contribute to the pathophysiology of atherosclerosis.

Katrine further showed how to inhibit the upstream cholesterol crystal-induced complement activation. Thus, this could be a new strategy for treatment and prevention of atherosclerosis.

In particular, she found that alpha-cyclodextrin may be a novel inhibitor of cholesterol crystal-induced inflammation

The photo shows Katrine Pilely with the Assessment Committee. Professor Seppo Meri from University of Helsinki (left) and Associate Professor Eivind Samstad from Norwegian University of Science and Technology (right).

Katrine Pilely now puts her knowledge to work in HCP coverage analysis

Katrine Pilely joined the Host Cell Protein Analysis Team at Alphalyse on 1 January 2019.

At Alphalyse she now focuses on implementing and also improving the application of immunopurification and mass spectrometry to HCP detection.

We find great use for her knowledge in our HCP ELISA antibody coverage analysis. Katrine is thus co-author of the Poster on the subject, presented at the BEPBA Host Cell Protein conference in San Pedro, California this May.