Modifications

Characterization of post translational modifications

Most biologics contain post-translational modifications (PTMs) and the characterization of these can be quite challenging.

Alphalyse offers a range of analytical services for determination of PTMs, including analysis of disulfide bridges and gly...

Most biologics contain post-translational modifications (PTMs) and the characterization of these can be quite challenging.

Alphalyse offers a range of analytical services for determination of PTMs, including analysis of disulfide bridges and glycosylations.

The modifications are typically investigated using a combination of protein chemistry and mass spectrometry. Thus, the analytical design of these experiments requires deep understanding of the technology. This includes protein chemistry methods, advanced mass spectrometry instrumentation and software for data interpretation.

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