mAb analysis

6 articles
Why mAbs call for orthogonal HCP analysis techniques

Critical reasons why mAbs call for orthogonal HCP analysis techniques

Question: HCP-ELISAs show our mAb is pure. So why do we need orthogonal analysis? We produce a monoclonal antibody (mAb) product,...

May 21. 2021 | Thomas Kofoed |

Investigation of ubiquitin in purified antibody products

Question: Should we worry about ubiquitin in our mAb? Our process-specific HCP ELISA did not detect any Host Cell Proteins (HCPs) in...

Mar 30. 2021 | Ejvind Mørtz |
mAb analysis by peptide mapping

Assessing and monitoring the quality of therapeutic mAb products

Question: Which analyses should be part of mAb characterization? I need to ensure the quality and consistency of my mAbs. Which analyses...

Nov 25. 2019 | Thomas Kofoed |

How to characterize antibody glycosylation by HILIC-MS

Question: How do I characterize the N-glycosylation of my antibody? What is N-glycosylation and how do I characterize the N-glycosylation of my...

Mar 4. 2019 | Thomas Kofoed |

4 reasons to perform N-terminal protein sequence analysis by Edman

Question: How should I sequence mAbs? How do I obtain the N-terminal sequences of the heavy chain and light chain of my...

Apr 26. 2017 | Ejvind Mørtz |

Why disulfide bridges are critical quality attributes of biologics

Question: Can disulfide bridges influence the stability of my protein? The activity of my biopharmaceutical protein is low, and I suspect that...

Mar 7. 2017 | Thomas Kofoed |
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