mAb analysis
6 articles
Critical reasons why mAbs call for orthogonal HCP analysis techniques
Question: HCP-ELISAs show our mAb is pure. So why do we need orthogonal analysis? We produce a monoclonal antibody (mAb) product,...
Investigation of ubiquitin in purified antibody products
Question: Should we worry about ubiquitin in our mAb? Our process-specific HCP ELISA did not detect any Host Cell Proteins (HCPs) in...
Assessing and monitoring the quality of therapeutic mAb products
Question: Which analyses should be part of mAb characterization? I need to ensure the quality and consistency of my mAbs. Which analyses...
How to characterize antibody glycosylation by HILIC-MS
Question: How do I characterize the N-glycosylation of my antibody? What is N-glycosylation and how do I characterize the N-glycosylation of my...
4 reasons to perform N-terminal protein sequence analysis by Edman
Question: How should I sequence mAbs? How do I obtain the N-terminal sequences of the heavy chain and light chain of my...
Why disulfide bridges are critical quality attributes of biologics
Question: Can disulfide bridges influence the stability of my protein? The activity of my biopharmaceutical protein is low, and I suspect that...