Investigation of ubiquitin in purified antibody products

Question: Should we worry about ubiquitin in our mAb? Our process-specific HCP ELISA did not detect any Host Cell Proteins (HCPs) in...

Mar 30. 2021 | Ejvind Mørtz |

What are Host Cell Proteins (HCPs)?

Question: What are Host Cell Proteins and how are they measured? I recently met the term Host Cell Proteins (HCPs) in relation...

Jan 10. 2019 | Ejvind Mørtz |
What is SWATH?

What is SWATH mass spectrometry and its advantages?

Host Cell Proteins (HCPs) in protein biopharmaceuticals can be analyzed by the mass spectrometry SWATH analysis. It provides both identification...

Jun 22. 2017 | Thomas Kofoed |
Analysis method for Mw HCPs (small HCPs) below 20 kDa

Identification of small host cell proteins (small Mw HCPs)

Question: How do I identify HCPs with low molecular weight? I work on a drug substance protein with a mass of 15...

Oct 11. 2016 | Ejvind Mørtz |

Host Cell Protein monitoring in process development – using mass spec

Mass spectrometry based Host Cell Protein identification and quantification The Mass Spec Host Cell Protein (HCP) assay is applied for monitoring...

Oct 2. 2009 | Ejvind Mørtz |
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