Analysis of Host Cell Protein
8 articles
Can I use commercial HCP ELISA kits for my clinical trial application?
Question: My company uses a commercial HCP ELISA kit for host cell protein analysis of clinical phase 1 material. We hear...
Simple way to perform label-free quantification of Host Cell Proteins
Question: I find it difficult to get an accurate label-free quantification of Host Cell Proteins with LC-MS. It also seems that...
What is SWATH & why is it an advantage in Host Cell Protein analysis?
Host Cell Proteins (HCPs) in protein biopharmaceuticals can be analyzed by the mass spectrometry SWATH analysis - for both identification...
Identification of small host cell proteins (small Mw HCPs)
Question: I work on a drug substance protein with a mass of 15 kDa. I would expect small host cell protein...
Host Cell Protein monitoring in process development – using mass spec
Mass spectrometry based Host Cell Protein identification and quantification The Mass Spec Host Cell Protein (HCP) assay is applied for monitoring...