Analysis of Host Cell Protein

7 articles
elisa-coverage

Can I use commercial HCP ELISA kits for FDA approval of clinical trial application?

Question:   My company uses a commercial HCP ELISA kit for host cell protein analysis of clinical phase 1 material. We hear...

Jul 10. 2019 | Ejvind Mørtz |

What are Host Cell Proteins (HCPs)?

Question:   I recently met the term Host Cell Proteins (HCPs) in relation to process development and production of biopharmaceuticals. What are...

Jan 10. 2019 | Ejvind Mørtz |
1000 proteins quantified in e. coli mock lysate - HCP

Simple way to perform label-free quantification of Host Cell Proteins

Question:   I find it difficult to get an accurate label-free quantification of Host Cell Proteins with LC-MS. It also seems that my...

Jun 25. 2018 | Ejvind Mørtz |

What are ‘Jackpot HCPs’? Do I need a ‘lucky goat’ for precise ELISA results?

Question:   I tested two different HCP ELISA kits on my biopharmaceutical. Why do they give different results and which one is...

May 28. 2018 | Anette Draborg |
What is SWATH?

What is SWATH and why is it an advantage for Host Cell Protein analysis?

Host Cell Proteins (HCPs) in protein biopharmaceuticals can be analyzed by mass spectrometry - for both identification and quantification of...

Jun 22. 2017 | Thomas Kofoed |
Analysis method for Mw HCPs (small HCPs) below 20 kDa

Identification of small host cell proteins (low Mw HCPs)

Question: Could you suggest an analysis method to detect low Mw HCPs (small HCPs) below 20 kDa? I work on a drug...

Oct 11. 2016 | Ejvind Mørtz |

Host Cell Protein monitoring & control in process development

Mass spectrometry based Host Cell Protein identification and quantification Here the Mass Spec Host Cell Protein (HCP) assay is applied for...

Oct 2. 2009 | Ejvind Mørtz |
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